Key takeaway
Before, during, and after a monitored treatment session — including the two-hour observation and why you need a ride home.
Before the visit A prescriber evaluates whether SPRAVATO® is appropriate, reviews your medical history (including blood pressure and any history of substance use), and asks about other medications. Sedating medicines such as benzodiazepines and opioids, as well as psychostimulants and MAOIs, can matter, so tell the care team about everything you take. Plan a ride home in advance.
During the visit - Your blood pressure is checked before the dose. - You use the nasal spray device yourself while a healthcare provider watches. - You then rest in the treatment setting while staff monitor you.
The observation period Under the SPRAVATO® REMS, every patient is monitored for at least two hours after each dose, until a healthcare provider decides it is safe to leave. Blood pressure is rechecked during this time. Common short-term effects listed in the label include dissociation, dizziness, nausea, sedation, vertigo, reduced sensation, anxiety, lethargy, increased blood pressure, vomiting, and feeling drunk.
After the visit Do not drive or operate machinery until the next day after a restful sleep. Arrange transportation home.
How often are visits? Dosing depends on which approved use applies and the phase of treatment, and is set by your prescriber. Treatment typically starts with more frequent visits that later become less frequent, but there is no single fixed schedule for everyone.
General information from the FDA prescribing information and REMS materials — not medical advice.
This page is informational and is not medical advice.