The short version
- Approved with an oral antidepressant for adults with MDD and acute suicidal ideation or behavior
- Reduces depressive symptoms; not proven to prevent suicide
- Not a substitute for hospitalization when hospitalization is needed
- In crisis: call or text 988, or call 911
The approved use
SPRAVATO®, taken together with an oral antidepressant, is FDA-approved for adults with major depressive disorder (MDD) who are experiencing acute suicidal ideation or behavior. In studies, it reduced depressive symptoms rapidly; it has not been shown to prevent suicide or reduce suicidal behavior itself, and it does not replace hospitalization when that is needed.
If you are in crisis right now
Call or text 988 (Suicide & Crisis Lifeline) or call 911. SPRAVATO® treatment is planned care, not an emergency response.
What treatment involves
Dosing happens only at a certified treatment center, with at least two hours of monitoring after each dose. SPRAVATO® carries boxed warnings for sedation, dissociation, respiratory depression, abuse and misuse, and suicidal thoughts and behaviors, and it is not approved for children or adolescents.
Source: FDA prescribing information for SPRAVATO® (esketamine) nasal spray, NDA 211243. General information, not medical advice.
What a course of treatment looks like
- 1
Consultation and eligibility
A qualified healthcare professional reviews your diagnosis, treatment history, medicines, and safety risks before determining whether SPRAVATO® is appropriate.
- 2
Insurance authorization
If required, the clinic submits clinical documentation to the insurer. Requirements and timing vary by plan and are not guaranteed.
- 3
A monitored treatment visit
You self-administer the prescribed nasal spray under direct observation in a certified healthcare setting.
- 4
Observation and transportation
The clinic monitors you for at least two hours after each dose. Arrange a ride home and do not drive until the next day after restful sleep.
- 5
Individualized follow-up
The prescriber assesses benefit, tolerability, and ongoing need. Dose and frequency depend on the labeled indication and individual response.
Eligibility
Could SPRAVATO® be an option to discuss?
A clinic confirms all of this at your consultation. Use it to see whether a consultation is worth booking.
- Adults 18 and older
- Major depressive disorder with acute suicidal ideation or behavior
- Treated together with an oral antidepressant at a certified center
Questions people ask
Does SPRAVATO® prevent suicide?
No. It has been shown to reduce depressive symptoms in this group, but it has not been shown to prevent suicide or reduce suicidal behavior.
What should I do in a crisis?
Call or text 988 (Suicide & Crisis Lifeline) or call 911 immediately. Do not wait for a SPRAVATO® appointment.
Other conditions we cover
SPRAVATO® treatment centers near you
Browse clinics by town or county, or read more about treatment in United States.
This guide is general information, not medical advice. Only a prescriber who knows your history can say whether SPRAVATO® is right for you. If you are in crisis, call or text 988.